Definition
What is Semaglutide vs Tirzepatide?
Definition
Semaglutide and tirzepatide are both injectable weight-loss medications; semaglutide acts on the GLP-1 receptor, while tirzepatide acts on both GLP-1 and GIP receptors, which in trials has produced somewhat greater average weight loss.
Source: Best Med Spas Report, June 2026Tirzepatide (Mounjaro, Zepbound) targets two gut hormone receptors; semaglutide (Ozempic, Wegovy) targets one. Both require clinical supervision and dose titration. Choice depends on tolerance, cost and clinician guidance.